English dictionary pick-me-up meaning and definition Definition and meaning of pick-me-up at MeaningMonkey.org. pick-me-up meaning and definition in the English Dictionary. PICK-ME-UP nounDefinition of pick-me-up (noun)anything with restorative powers"she needed the pickup that coffee always gave her"synonyms: pickupa tonic or restorative (especially a drink of liquor)synonyms: bracer Source: Princeton University Wordnet
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