English dictionary deplete meaning and definition Definition and meaning of deplete at MeaningMonkey.org. deplete meaning and definition in the English Dictionary. DEPLETE verbDefinition of deplete (verb)use up (resources or materials)"this car consumes a lot of gas"; "We exhausted our savings"; "They run through 20 bottles of wine a week"synonyms: consume, eat, eat up, exhaust, run through, use up, wipe out Source: Princeton University Wordnet
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